Apicomplexan lineage-specific polytopic membrane proteins in Cryptosporidium parvum
نویسندگان
چکیده
منابع مشابه
Complete genome sequence of the apicomplexan, Cryptosporidium parvum.
The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Pla...
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Cryptosporidium parvum and C. hominis are related protozoan pathogens which infect the intestinal epithelium of humans and other vertebrates. To explore the evolution of these parasites, and identify genes under positive selection, we performed a pairwise whole-genome comparison between all orthologous protein coding genes in C. parvum and C. hominis. Genome-wide calculation of the ratio of non...
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It has been proposed that the aggregation of nascent transmembrane segments of polytopic proteins is prevented by chaperones present in the endoplasmic reticulum membrane; now the first experimental support for this proposal has been reported.
متن کاملFunctional characterization of an evolutionarily distinct phosphopantetheinyl transferase in the apicomplexan Cryptosporidium parvum.
Recently, two types of fatty acid synthases (FASs) have been discovered from apicomplexan parasites. Although significant progress has been made in characterizing these apicomplexan FASs, virtually nothing was previously known about the activation and regulation of these enzymes. In this study, we report the discovery and characterization of two distinct types of phosphopantetheinyl transferase...
متن کاملThe Cryptosporidium parvum ApiAP2 gene family: insights into the evolution of apicomplexan AP2 regulatory systems
We provide the first comprehensive analysis of any transcription factor family in Cryptosporidium, a basal-branching apicomplexan that is the second leading cause of infant diarrhea globally. AP2 domain-containing proteins have evolved to be the major regulatory family in the phylum to the exclusion of canonical regulators. We show that apicomplexan and perkinsid AP2 domains cluster distinctly ...
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ژورنال
عنوان ژورنال: Journal of Parasitic Diseases
سال: 2020
ISSN: 0971-7196,0975-0703
DOI: 10.1007/s12639-020-01209-5